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Improvements in quality of life associated with insulin analogue therapies in people with type 2 diabetes: Results from the A1chieve observational study

Siddharth Shah, Alexey Zilov, Rachid Malek, Pradana Soewondo, Ole Bech and Leon Litwak

Diabetes Research and Clinical Practice, Issue 3, Volume 94, pages 364 - 370

Received 20 September 2011, Revised 10 October 2011, Accepted 13 October 2011, Published online Nov-2011


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References

Label Authors Title Source Year
[1]

References in context

  • It is widely recognised that having type 2 diabetes (T2DM) has a negative impact on quality of life (QoL) [1].
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R.R. Rubin, M. Peyrot Quality of life and diabetes Crossref. Diabetes Metab Res Rev. 1999;15(3):205-218 1999
[2]
M. Peyrot, R.R. Rubin, K. Khunti Addressing barriers to initiation of insulin in patients with type 2 diabetes Crossref. Primary Care Diabetes. 2010;4(Suppl. 1):S11-S18 2010
[3]
C.J. Currie, C.L. Morgan, C.D. Poole, P. Sharplin, M. Lammert, P. McEwan Multivariate models of health-related utility and the fear of hypoglycaemia in people with diabetes Crossref. Curr Med Res Opin. 2006;22:1523-1534 2006
[4]
S.A. Brunton, S.N. Davis, S.M. Renda Overcoming psychological barriers to insulin use in type 2 diabetes Crossref. Clin Cornerstone. 2006;8(Suppl. 2):S19-S26 2006
[5]
W.H. Polonsky, L. Fisher, S. Guzman, L. Villa-Caballero, S.V. Edelman Psychological insulin resistance in patients with type 2 diabetes: the scope of the problem Crossref. Diabetes Care. 2005;28:2543-2545 2005
[6]
D.G. Marrero Overcoming patient barriers to initiating insulin therapy in type 2 diabetes mellitus Clin Cornerstone. 2007;8(2):33-40 2007
[7]
M.J. Calvert, R.J. McManus, N. Freemantle Management of type 2 diabetes with multiple oral hypoglycaemic agents or insulin in primary care: retrospective cohort study Br J Gen Pract. 2007;57(539):455-460 2007
[8]

References in context

  • Indeed, it is known that measured QoL improves with better glycaemic control [8].
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  • In A1chieve, QoL significantly improved for people irrespective of prior insulin status, and it is known that improvements in glycaemic control are associated with improvements in QoL [8].
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A.M. Jacobson Impact of improved glycemic control on quality of life in patients with diabetes Crossref. Endocr Pract. 2004;10(6):502-508 2004
[9]

References in context

  • Literature reporting the effect of insulin analogues on QoL is scarce, with one recent systematic review investigating basal insulin analogues being unable to identify any suitable trials measuring QoL in people with T2DM [9].
    Go to context

N. Waugh, E. Cummins, P. Royle, C. Clar, M. Marien, B. Richter, et al. Newer agents for blood glucose control in type 2 diabetes: systematic review and economic evaluation Health Technol Assess. 2010;14(36):1-248 2010
[10]

References in context

  • As the largest observational study ever conducted in insulin therapy, and with a broad geographical base, the A1chieve study evaluated the safety and effectiveness of starting insulin with, or switching to, insulin analogue-based regimens in a large and diverse population from a wide variety of clinical environments [10].
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S.N. Shah, L. Litwak, J. Haddad, P.N. Chakkarwar, I. Hajjaji The A1chieve study: a 60 000-person, global, prospective, observational study of basal, meal-time, and biphasic insulin analogs in daily clinical practice Abstract, Full-text, PDF, Crossref. Diabetes Res Clin Pract. 2010;88(Suppl. 1):S11-S16 2010
[11]

References in context

  • Health-related quality of life (HRQoL) was measured using the EQ-5D questionnaire [11] at baseline and after 24weeks of therapy with insulin analogues.
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EuroQol Group EuroQol—a new facility for the measurement of health-related quality of life Health Policy. 1990;16(3):199-208 1990
[12]

References in context

  • In one 16-week, randomised controlled trial in 308 insulin-naïve people with T2DM, the Diabetes Health Profile and the World Health Organization's Diabetes Treatment Satisfaction Questionnaire (DTSQ) were used to measure the effect of twice- or three-times daily biphasic insulin aspart 30 plus metformin compared with OGLDs alone [12].
    Go to context

O. Ushakova, V. Sokolovskaya, A. Morozova, F. Valeeva, O. Zanozina, O. Sazonova, et al. Comparison of biphasic insulin aspart 30 given three times daily or twice daily in combination with metformin versus oral antidiabetic drugs alone in patients with poorly controlled type 2 diabetes: a 16-week, randomized, open-label, parallel-group trial conducted in Russia Crossref. Clin Ther. 2007;29(11):2374-2384 2007
[13]

References in context

  • For example, in the Indian cohort of the 26-week IMPROVE observational study, QoL was measured using the DiabMedSat questionnaire in 349 people with T2DM being treated with biphasic insulin aspart 30 [13].
    Go to context

A.K. Mukherjee, V.S. Reddy, S. Shah, A.K. Jhingan, P. Ramakrishnan, V. Prusty, et al. Quality of life as a key indicator of patient satisfaction and treatment compliance in people with type 2 diabetes mellitus in the IMPROVE study: a multicentre, open label, non-randomised, observational trial J Indian Med Assoc. 2009;107(7):464-470 2009
[14]

References in context

  • Similar observations were made in the Iranian cohort of the IMPROVE™ study, with a significantly higher DiabMedSat score, including significant increases in all three subscale scores, at study end in 478 people who were insulin naïve or insulin experienced [14].
    Go to context

A. Esteghamati, R. Rajabian, M. Amini, A. Bahrami, M.E. Khamseh, M. Afkhami-Ardekani, et al. The safety and efficacy of biphasic insulin aspart 30 (BIAsp 30) in Iranians with type 2 diabetes: an open-label, non-randomised, multi-centre observational study—the Iran subgroup of the IMPROVE™ study Endokrynol Pol. 2010;61(4):364-370 2010
[15]
T.R. Hajos, F. Pouwer, R. de Grooth, F. Holleman, J.W. Twisk, M. Diamant, et al. Initiation of insulin glargine in patients with Type 2 diabetes in suboptimal glycaemic control positively impacts health-related quality of life. A prospective cohort study in primary care Crossref. Diabet Med. 2011;28(9):1096-1102 2011
[16]

References in context

  • It is also recognised that hypoglycaemia has an impact on QoL [16], and it is possible that the reduction in events seen in previous insulin users in this study also contributed to an improvement in score.
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Barendse S, Singh H, Frier BM, Speight J. The impact of hypoglycaemia on quality of life and related patient-reported outcomes in type 2 diabetes: a narrative review. Diabet Med, in press.
[17]

References in context

  • However, the EQ-5D questionnaire is known to be a validated, reliable and responsive instrument in T2DM [17], and is thus a reasonable choice for the purposes of the current study.
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M.F. Janssen, E.I. Lubetkin, J.P. Sekhobo, A.S. Pickard The use of the EQ-5D preference-based health status measure in adults with Type 2 diabetes mellitus Crossref. Diabet Med. 2011;28(4):395-413 2011
[18]

References in context

  • It will be used alongside other measures in a major upcoming European prospective observational study [18].
    Go to context

Bradley C, de Pablos-Velasco P, Parhofer KG, Eschwège E, Gönder-Frederick L, Simon D. PANORAMA: a European study to evaluate quality of life and treatment satisfaction in patients with type-2 diabetes mellitus—study design. Primary Care Diabetes doi:10.1016/j.pcd.2011.04.004, in press.

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