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Switching from biphasic human insulin 30 to biphasic insulin aspart 30 in type 2 diabetes is associated with improved glycaemic control and a positive safety profile: Results from the A1chieve study

Nabil K. El Naggar, Pradana Soewondo, Mohammad E. Khamseh, Jian-Wen Chen and Jihad Haddad

Diabetes Research and Clinical Practice, 3, 98, pages 408 - 413

Published online Dec-2012


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Fig. 1 Mean HbA1c reductions in the overall group and by region. *p<0.001.

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References in context

  • Switching from BHI 30 to BIAsp 30 was associated with a significant mean reduction [SD] in HbA1c of 1.7% [−18 mmol/mol] (1.6) from a baseline of 9.1% [76 mmol/mol] (1.7) (p<0.001; Figure 1).
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Fig. 2 Mean pre-breakfast FPG reductions in the overall group and by region. *p<0.001. FPG, fasting plasma glucose.

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References in context

  • FPG was also significantly reduced by 3.0 (3.5) mmol/l from a baseline of 10.2 (3.4) mmol/l (p<0.001; pre-breakfast data shown in Figure 2).
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Table 1 Baseline characteristics of individuals who switched from biphasic human insulin 30 to biphasic insulin aspart 30.

Parameter Total cohort China South Asia East Asia North Africa Middle East/Gulf
N 6323 1191 2210 650 512 1634
Male, N (%) 3588 (56.9) 655 (55.0) 1442 (65.3) 340 (52.3) 219 (42.8) 899 (55.4)
Mean age, years (SD) 55.4 (12.5) 57.5 (15.5) 54.8 (10.7) 56.3 (11.4) 57.1 (12.2) 53.2 (12.5)
Mean body weight, kg (SD) 74.0 (14.8) 68.8 (10.9) 70.1 (11.4) 66.6 (13.1) 77.8 (13.2) 84.9 (16.3)
Mean BMI, kg/m2 (SD) 27.3 (5.1) 25.0 (3.2) 26.1 (3.9) 25.5 (4.6) 29.2 (5.4) 31.1 (5.8)
Mean duration of T2D, years (SD) 11.1 (6.6) 10.6 (6.6) 10.1 (5.3) 10.4 (7.7) 12.4 (7.7) 12.5 (6.9)
Mean time to insulin initiation,years (SD) 7.3 (5.4) 7.4 (5.9) 7.1 (4.4) 7.5 (6.6) 7.2 (6.2) 7.5 (5.3)
Mean duration on insulin therapy, years (SD) 3.3 (3.3) 3.4 (3.2) 3.0 (2.6) 2.8 (3.1) 5.2 (5.2) 5.1 (4.7)
Mean HbA1c,% (SD) [mmol/mol] 9.1 (1.7) [76] 8.7 (2.1) [72] 9.1 (1.4) [76] 9.5 (1.9) [80] 9.0 (1.6) [75] 9.4 (1.8) [79]

References in context

  • Mean body mass index (BMI) was 27.3kg/m2 and mean body weight was 74.0kg (Table 1).
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BMI, body mass index; SD, standard deviation

Table 2 Post-breakfast plasma glucose reductions in the overall group and by region.

N All 2961 China 722 South Asia 1009 East Asia 239 North Africa 198 Middle East/Gulf 724
Post-breakfast PG (mmol/l), mean (SD)
Baseline 14.2 (4.3) 12.9 (4.2) 15.1 (3.9) 14.7 (4.8) 14.1 (4.3) 14.3 (4.4)
Week 24 9.9 (2.8) 9.1 (2.0) 10.8 (3.2) 10.3 (3.4) 10.2 (2.8) 9.2 (2.4)
Change from baseline –4.3 (4.3) –3.8 (4.3) –4.4 (4.0) –4.3 (5.2) –3.9 (4.9) –5.0 (4.2)
[P-value] [<0.001] [<0.001] [<0.001] [<0.001] [<0.001] [<0.001]

References in context

  • PPG following breakfast was significantly reduced in the overall population and in individual countries by Week 24 versus baseline (Table 2).
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PG, plasma glucose; SD, standard deviation


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