Safety and effectiveness of biphasic insulin aspart 30 in a Bangladeshi subgroup of type 2 diabetic patients switched from biphasic human insulin 30: A sub-analysis of the A1chieve study
Diabetes Research and Clinical Practice, pages S30 - S34
Published online Aug-2013
To determine the safety and effectiveness of biphasic insulin aspart 30 (BIAsp 30) therapy in Bangladeshi type 2 diabetes (T2D) patients switched from biphasic human insulin (BHI) as a sub-analysis of the A1chieve study.
Bangladeshi patients switched from BHI to BIAsp 30 at the discretion of their physicians were included. The primary outcome was the incidence of serious adverse drug reactions (SADRs), including major hypoglycaemia. Secondary outcomes comprised changes from baseline to Week 24 in the number of hypoglycaemic events, glycated haemoglobin A1c (HbA1c), fasting plasma glucose (FPG), postprandial plasma glucose (PPPG), systolic blood pressure and body weight. Quality of life (QoL) was evaluated at baseline and Week 24 using the EQ-5D questionnaire.
A total of 82 patients (mean age ± SD: 52.3±12.2 years; body mass index: 25.6±3.3kg/m2) with a mean diabetes duration of 9.5±5.5 years and mean duration on insulin of 2.5±2.4 years were included. The mean BIAsp 30 dose was 0.49±0.20 U/kg at baseline and 0.47±0.17 U/kg at Week 24. No SADRs were reported. No events of hypoglycaemia (overall, major, minor or nocturnal) were reported at Week 24. Mean HbA1c, FPG and PPPG levels improved by –2.5±1.3%, –65.0±31.8 mg/dL and –119.3±48.7 mg/dL, respectively, over 24 weeks. QoL also improved (mean change from baseline: +28.5±12.9 points).
Switching from BHI to BIAsp 30 therapy improved blood glucose control and was well-tolerated in this Bangladeshi subgroup.
Keywords: Bangladesh, Type 2 diabetes mellitus, Biphasic insulin aspart 30, Biphasic human insulin 30, A1chieve.
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a BIRDEM Hospital, Dhaka, Bangladesh BIRDEM Hospital, Dhaka, Bangladesh
b Mymensingh Medical College Hospital, Mymensingh, Bangladesh Mymensingh Medical College Hospital, Mymensingh, Bangladesh
c Novo Nordisk Pharma (Pvt.) Ltd, Dhaka, Bangladesh Novo Nordisk Pharma (Pvt.) Ltd, Dhaka, Bangladesh
Corresponding author at: Endocrinology, BIRDEM Hospital, 122 Kazi Nazrul Islam Avenue, Shahbagh, Dhaka-1000, Bangladesh
© 2013 Published by Elsevier B.V.