A1chieve study reports

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Global

You are currently viewing the overall study results for Global.
Country or region: Global
Treatment: All
Pre-treatment 1: Insulin naïve
Pre-treatment 2: Insulin users

All results

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Parameters All Insulin naïve Insulin users
Number of participants 66726 44872 21854
Male (%) 37033 (55.6 %) 25702 (57.3 %) 11331 (51.9 %)
Female (%) 29623 (44.4 %) 19126 (42.7 %) 10497 (48.1 %)
Age (years) 54.0 53.2 55.6
Weight (kg) 72.9 71.7 75.3
BMI (kg/m2) 27.1 26.7 27.9
Duration of DM (years) 8.0 6.6 10.8
>2 OGLD 10981 8971 2010
No therapy 6010
HbA1c (%) 9.5 9.5 9.4
FPG (mmol/l) 10.9 11.2 10.5
PPPG (mmol/l) 15.1 15.5 14.2
Macrovascular complications, N (%) 17806 (27.2 %) 10321 (23.6 %) 7485 (34.3 %)
Microvascular complications, N (%) 35078 (53.5 %) 20753 (47.5 %) 14325 (65.7 %)

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Parameters Insulin naïve Insulin users
N 44872 21854
ADR 42 ( 0.1) 42 43 ( 0.2) 43
SADR 10 ( 0.0) 10 26 ( 0.1) 26
SAE 94 ( 0.2) 94 120 ( 0.5) 120

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Baseline value
1.1 7.3
0.3 2.2
0.1 0.8
Final value
1.2 2.5
0.3 0.6
0.0 0.0
N
38810 18581
38810 18581
38810 18581

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Baseline value
72.1 75.7
Final value
72.2 75.7
N
33716 16343
P*
<0.001 0.081

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N
0 21847
44804 21794
38690 18548

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N
5461 4631
12752 8922
14748 11570
14073 15727

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N
3998 3160
8197 5926
9882 7853
6980 7192

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Parameters Insulin naïve (baseline) Insulin naïve (week 24) Insulin naïve (change from baseline) Insulin naïve (number of patients) Insulin naïve (p-value)
LDL-C (mmol/L) 3.2 2.7 -0.4 10304 <0.001
HDL-C (mmol/L) 1.2 1.2 0.1 10189 <0.001
Triglycerides (mmol/L) 2.1 1.7 -0.4 11672 <0.001
SBP (mmHg) 134.0 127.3 -6.6 29595 <0.001

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Parameters Insulin users (baseline) Insulin users (week 24) Insulin users (change from baseline) Insulin users (number of patients) Insulin users (p-value)
LDL-C (mmol/L) 3.1 2.8 -0.3 7190 <0.001
HDL-C (mmol/L) 1.1 1.2 0.0 7117 <0.001
Triglycerides (mmol/L) 2.0 1.8 -0.3 8184 <0.001
SBP (mmHg) 134.7 129.0 -5.7 15690 <0.001

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Baseline value
9.5 9.4
Final value
7.4 7.6
N
30369 14292
P*
<0.001 <0.001

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Baseline value
11.2 10.5
15.5 14.2
Final value
7.1 7.2
9.8 9.7
N
33087 15104
23334 10408
P*
<0.001 <0.001
<0.001 <0.001

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N
38639 33311

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N
18611 15791

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N
16746 24093
15128 23449
17721 26176
14085 22392
19115 24923
P*
<0.0001 <0.0001
<0.0001 <0.0001
<0.0001 <0.0001
<0.0001 <0.0001
<0.0001 <0.0001

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Best imaginable health state

N
29248 29248
P*
<0.001 <0.001

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N
7854 10173
6839 9410
7990 10551
6060 8615
9352 10945
P*
<0.0001 <0.0001
<0.0001 <0.0001
<0.0001 <0.0001
<0.0001 <0.0001
<0.0001 <0.0001

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Best imaginable health state

N
12501 12501
P*
<0.001 <0.001

Glossary

BIAsp

Biphasic insulin aspart

BMI

Body mass index

FPG

Fasting plasma glucose

HbA1c

Glycosylated haemoglobin A1c

IAsp

Insulin aspart

OGLD

Oral glucose lowering drugs

PPPG

Post prandial plasma glucose

* P is only available for N ≥ 100